The research examines the role of job stress in work-life balance among women nursing paramedics at Medan City Hospital. This research used a quantitative method. A total of 324 women nursing paramedics at Medan City Hospital participated in this research. The measurement was conducted using the job stress and work-life balance scales. Data on this research was analyzed using a linear regression test. The results of this research show a role of job stress and work-life balance among female nursing paramedics because the statistic shows that T value -8.8260  > T table 1.960 and p = 0,000 < 0,050. Another result is that the job stress of women nursing paramedics is categorized as high, and the work-life balance of women nursing paramedics is categorized as low. Therefore, it is recommended that further research be carried out with qualitative methods or mixed design and consider other variables.
                        
                        
                        
                        
                            
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