<![CDATA[Background : Parkinson's Disease (PD) remains a complex and challenging condition, with ongoing research shedding light on its multifaceted nature. This review synthesizes recent findings on the genetic basis, autonomic dysfunction, lifestyle impacts, treatment advancements, and environmental considerations related to PD. By analyzing recent literature, this review aims to provide a comprehensive understanding of current trends and implications for future research and clinical practice. Methods : Literature searches were performed using databases including PubMed, Google Scholar, and SINTA with search terms such as "Parkinson’s" "Genetics" "lifestyle" and "environtment" Only systematic reviews of peer-reviewed articles, reports, and case studies were selected for inclusion. Discussion : The complexity of Parkinson's Disease (PD) and the necessity for a multidimensional approach to its understanding and management. Genetic research highlights opportunities for personalized medicine, while insights into autonomic dysfunction underscore the importance of comprehensive clinical evaluations. Lifestyle and environmental factors are increasingly recognized for their roles in PD prevention and management, advocating for a holistic approach. Advancements in treatment, including immunotherapy and neural grafting, provide hope for improved patient outcomes, though significant challenges remain in translating research into clinical practice. Conclusion : This review highlights the multifaceted nature of Parkinson's Disease, emphasizing the importance of integrating genetic, lifestyle, and environmental considerations into clinical practice. Recent advancements in understanding PD's underlying mechanisms and therapeutic innovations provide a foundation for improved management and prevention. A holistic and multidisciplinary approach is essential to enhance patient outcomes and address the challenges in diagnosing and treating this complex neurodegenerative disorder.]]>
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