Journal of Bio-molecule Research And Engineering
Vol 2 No 1 (2023)

Evaluation on Bioactive Secondary Metabolites from Fingerroot (Boesenbergia rotunda) as a Potent α-Glucosidase Inhibitor: In silico Study: In silico Study

Firdaus, Yazdaniar Fajri Halimi (Unknown)
Hariyanto, Nova Alfian (Unknown)
Kurnia, Irmayanti Tri (Unknown)
Lestari, Dinda Ayu (Unknown)
Suwandari, Suhartini (Unknown)
Haq, Kautsar Ul (Unknown)
Phuwapraisirisan, Preecha (Unknown)
Ramadhan, Rico (Unknown)

Article Info

Publish Date
10 Jun 2023

Abstract

Fingerroot (Boesenbergia rotunda) is a medicinal plant that has been reported to have anti-diabetic properties. However, the mechanism of action and the active compounds responsible for this effect are not well understood. In this study, we performed molecular docking study of isolated compound from fingerroot against N-terminal-human intestinal maltase-glucoamylase, one class of α-glucosidase. Inhibiting enzymatic activity of alpha glucosidase could potentially control sugar levels. In addition to panduratin A showing moderate inhibition activity against N-terminal-human intestinal maltase-glucoamylase.

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Journal Info
Journal of Bio-molecule Research And Engineering
Website

Abbrev

biome

Publisher

Universitas Airlangga

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology

Description

Journal of Bio-Molecule Research and Engineering [JBIOME] is a peer-reviewed, open-access journal that publishes original research articles, review articles, as well as short communication in the following areas: Biochemistry, Biotechnology, Bioengineering, Microbiology, Molecular Biology, Synthetic ...