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Suwandari, Suhartini
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology

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Evaluation on Bioactive Secondary Metabolites from Fingerroot (Boesenbergia rotunda) as a Potent α-Glucosidase Inhibitor: In silico Study: In silico Study Firdaus, Yazdaniar Fajri Halimi; Hariyanto, Nova Alfian; Kurnia, Irmayanti Tri; Lestari, Dinda Ayu; Suwandari, Suhartini; Haq, Kautsar Ul; Phuwapraisirisan, Preecha; Ramadhan, Rico
Journal of Bio-Molecule Research and Engineering Vol 2 No 1 (2023)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbiome.v2i1.51981

Abstract

Fingerroot (Boesenbergia rotunda) is a medicinal plant that has been reported to have anti-diabetic properties. However, the mechanism of action and the active compounds responsible for this effect are not well understood. In this study, we performed molecular docking study of isolated compound from fingerroot against N-terminal-human intestinal maltase-glucoamylase, one class of α-glucosidase. Inhibiting enzymatic activity of alpha glucosidase could potentially control sugar levels. In addition to panduratin A showing moderate inhibition activity against N-terminal-human intestinal maltase-glucoamylase.
Evaluation potency of Boesenbergia rotunda as antioxidant achieved by free radicals scavenging activities Dinda; Kurnia, Irmayanti Tri; Hariyanto, Nova Alfian; Suwandari, Suhartini; Firdaus, Yazdaniar Fajri Halimi; Mahmuda, Nur Fariha; Phuwapraisirisan, Preecha; Ramadhan, Rico
Journal of Bio-Molecule Research and Engineering Vol 2 No 1 (2023)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbiome.v2i1.52066

Abstract

Boesenbergia rotunda has antioxidant potential to inhibit free radicals. Antioxidant activity was determined by free radical scavenging activity against DPPH, ABTS and Cuprac. The results showed that the hexane extract of Boesenbergia rotunda had a strong percent antioxidant activity with a value of 91.38, while ascorbic acid as a positive control had a value of 99.85. Antioxidant activity test results showed that hexane and dichloromethane extracts have DPPH, ABTS, and cuprac free radical scavenging activities
Assessment of the Phytochemicals and Antioxidant Activity of Baccaurea bracteata Müll.Arg. and Macaranga lowii King ex Hook.f. from East Kalimantan Dinda; Suwandari, Suhartini; Kurnia, Irmayanti Tri; Hasan, Muhammad Iqbal; Artama, Riro Iraga; Phontree, Kiettipum; Ramadhan, Rico
Journal of Bio-Molecule Research and Engineering Vol 2 No 2 (2023)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbiome.v2i2.65361

Abstract

This study investigated the total phenolic content and antioxidant activity of Baccaurea bracteata Müll.Arg. and Macaranga lowii King ex Hook.f. from East Kalimantan. The leaves of these plant extracts were evaluated for their total phenolic content (TPC) and antioxidant activity, utilizing the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay. The findings indicated that Baccaurea bracteata Müll.Arg. demonstrated superior antioxidant activity with a percent inhibition (PI) value of 68.31 ± 0.11%. This research highlights Baccaurea bracteata Müll.Arg. as a promising source of natural antioxidants, characterized by high total phenolic content of 14.76 ± 1.98 mgGAE/g.
Co-Authors Artama, Riro Iraga Dinda Firdaus, Yazdaniar Fajri Halimi Haq, Kautsar Ul Hariyanto, Nova Alfian Hasan, Muhammad Iqbal Kurnia, Irmayanti Tri Lestari, Dinda Ayu Mahmuda, Nur Fariha Phontree, Kiettipum Phuwapraisirisan, Preecha Rico Ramadhan, Rico