Dinasti Health and Pharmacy Science
Vol. 1 No. 1 (2023): Dinasti Health and Pharmacy Science (July 2023)

Effect of leaf ethyl acetate fraction Binahong (Anredera Cordifolia (Ten.) Steenis) on Uric Acid Levels of Hyperuricemia Male Mice

Hayati, Rahmi (Unknown)
Bimas Saputra, Ebit (Unknown)



Article Info

Publish Date
13 Jul 2023

Abstract

A study on the effect of the ethyl acetate fraction of binahong leaves ( Anredera cordifolia (Ten.) Steenis) on uric acid levels in hyperuricemia male mice has been carried out. A total of 25 male mice were first induced with chicken liver juice 25 g/kg orally for 14 days to get hyperuricemia test animals. The test animals were divided into six groups, namely those that received 12.5 mg/kg, 25 mg/kg and 50 mg/kg fractions, positive control, negative control and 10 mg/kg allopurinol as a comparison. Data analysis used two-way analysis of variance (ANOVA) followed by Duncan's Multiple Range T-test with 95% confidence intervals. This study stated that the fraction used lowered blood uric acid levels. The best reducing effect of the fractions was shown by a dose of 50 mg/kg. This study shows that the ethyl acetate fraction of A. cordifolia exhibits antihyperuricemia activity which has the potential for drug development in the future.

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Journal Info

Abbrev

DHPS

Publisher

Subject

Health Professions

Description

Dinasti Health and Pharmacy Science (DHPS) focuses on the health and pharmaceutical sciences including the preventive, promotive, curative and rehabilitative domains which publishes "original articles" and "review articles". The scientific scope of the DHPS Journal includes: Public health Health ...