Eduvest - Journal of Universal Studies
Vol. 5 No. 3 (2025): Eduvest - Journal of Universal Studies

A Review on Mannich Base Derivatives Some of Natural Compounds: Antimicrobial Activities

Siburian, Eva (Unknown)
Hayun, Hayun (Unknown)
Suryadi, Herman (Unknown)

Article Info

Publish Date
30 Mar 2025

Abstract

This review explores the synthesis and antimicrobial potential of Mannich base derivatives derived from various natural compounds. The Mannich reaction, a versatile method in organic synthesis, enables structural modification of bioactive compounds to enhance their pharmacological properties, particularly antimicrobial activities. This study systematically reviews recent literature on the design, synthesis, and biological evaluation of these derivatives against bacterial and fungal pathogens. The findings demonstrate that Mannich base derivatives exhibit improved efficacy through multiple mechanisms of action, such as inhibition of cell wall synthesis, protein synthesis, and membrane disruption. The review highlights the relevance of Mannich-based structural optimization as a promising strategy in the development of novel antimicrobial agents.

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Journal Info
Eduvest - Journal of Universal Studies
Website

Abbrev

edv

Publisher

Green Publisher Indonesia

Subject

Aerospace Engineering Computer Science & IT Health Professions Neuroscience Social Sciences

Description

Eduvest - Journal of Universal Studies is a double blind peer-reviewed academic journal and open access to multidiciplinary fields. The journal is published monthly by Green Publisher Indonesia. Eduvest - Journal of Universal Studies provides a means for sustained discussion of relevant issues that ...