<![CDATA[Introduction: Emergency Department is the main entry point for hospital services in providing first aid to patients. One of the common infections in hospitals is nosocomial infection. The success of controlling nosocomial infections in infusion procedures is not determined by advanced equipment but by the behavior of healthcare workers in properly caring for patients.. Objectives: This study aims to analyze the relationship between knowledge level and nurses' compliance with the Standard Operating Procedure (SOP) for Infusion Placement in the Emergency Department of RSU dr. H. Koesnadi Bondowoso.. Methods: The study was conducted in January 2016 at the Emergency Department of RSU dr. H. Koesnadi Bondowoso. A correlational design with a cross-sectional approach was used. The population consisted of all nurses in the Emergency Department, with a total sample of 18 participants, selected using total sampling technique. Data were collected through questionnaires and observation sheets, then analyzed using SPSS "Spearman Rho" with a significance level of 5%. Results: The Spearman Rho test results at a 5% significance level (α) showed a P value of 0.001, concluding that p ≤ 0.05, so H1 is accepted, and Ho is rejected. This indicates a significant relationship between knowledge level and nurses' compliance with the SOP for Infusion Placement in the Emergency Department of RSU dr. H. Koesnadi Bondowoso. Conclusions: The findings demonstrate that nurses' knowledge is fundamental in adhering to the SOP for Infusion Placement, thereby preventing nosocomial infections.]]>
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