<![CDATA[Bacterial Resistance is defined as the inability of antibiotics to inhibit bacterial growth systemically, mainly caused by synthetic chemical antibiotics. Therefore, research on pharmacological alternatives to synthetic antibiotics with natural antibacterial agents is needed, one of which is the crude extract of mangrove snail (T. sulcata) tested against Escherichia coli (E. coli) bacteria. This study conducted phytochemical screening and antibacterial potential testing of T. sulcata meat extract. T. sulcata was extracted with a polar solution of Methanol pa 1:4. Antibacterial testing against E. coli was performed at different extract concentration levels (5,000 ppm - 20,000 ppm). The results showed antibacterial activity with the formation of inhibition zones in the E. coli bacterial suspension medium. ANOVA analysis indicated that the mangrove T. sulcate extract at various concentrations influenced the growth of E. coli bacteria. Differences in treatment demonstrated an increase in extract concentration, which was directly proportional to the diameter of the inhibition zone. Observations of changes in the inhibition zone indicated that T. sulcata extract exhibited bacteriostatic properties against E. coli, characterized by a reduction in the diameter of the inhibition zone at each treatment concentration level. The formation of inhibition zones is believed to be due to the activity of active compounds such as alkaloids, flavonoids, saponins, phenols, and terpenoids.]]>
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