<![CDATA[ABSTRACT Diabetes mellitus is a group of physiological dysfunctions due to insulin resistance and inadequateinsulin secretion characterized by hyperglycemia. Diabetic patients have an increased risk and severity ofperiodontitis. Therefore, additional periodontal treatment is required. Doxycycline is a broad-spectrum antibioticand has the anti collagenase ability to inhibit tissue damage. This study aims to determine the clinical response ofperiodontal tissue in patients with periodontitis with type 2 diabetes mellitus to doxycycline. This rapid review wasconducted online in May-July 2021 on randomized controlled trial articles about systemic doxycycline as anadjunctive periodontal treatment in periodontitis patients with type 2 diabetes mellitus. The search was carried outfrom three electronic databases, Pubmed NCBI, Cochrane Library, and Google Scholar concerning PRISMA analysisguidelines, using PICO strategy and the study quality assessed by SORT. Five articles were selected with goodevidence quality (level 1). Probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP),plaque index (PI), gingival index (GI), and gingival recession were evaluated. The result showed a more significantreduction in clinical parameters in periodontitis patients with type 2 diabetes mellitus who received additionalsystemic doxycycline treatment, except gingival recession. Systemic doxycycline as an adjunctive periodontaltreatment in periodontitis patients with type 2 diabetes mellitus gave a positive clinical response, with better resultsthan no other doxycycline treatment group. KEYWORDS: Doxycycline, periodontitis, diabetes mellitus]]>
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