Cermin Dunia Kedokteran
Vol 49 No 9 (2022): Neurologi

Manajemen Pasien Sirosis Hepatis saat Pandemi COVID-19

Guruh Dirga Saputra (Universitas Wijaya Kusuma, Surabaya, Indonesia)



Article Info

Publish Date
01 Sep 2022

Abstract

Penyakit coronavirus (COVID-19) mengakibatkan keadaan darurat kesehatan manusia secara global, tak terkecuali pasien penyakit hati, seperti sirosis hepatis yang dianggap lebih rentan terinfeksi virus karena respons imun yang terganggu. Kerusakan hati terkait COVID-19 berhubungan dengan sitotoksisitas virus langsung, aktivasi sistem kekebalan sistemik, kerusakan hati terkait penggunaan obat, reaktivasi penyakit hati yang sudah ada, dan hepatitis, sehingga tingkat morbiditas dan mortalitas terkait COVID-19 pada pasien sirosis relatif lebih tinggi. Hingga saat ini, masih belum ada pengobatan farmakologis yang terbukti efektif dan aman untuk pasien sirosis dengan COVID-19. Fokus utama tata laksana adalah mencegah perburukan dan menangani komplikasi.   Coronavirus disease (COVID-19) is a global human health emergency, and patients with liver diseases such as liver cirrhosis are considered more susceptible to viral infections due to an activation of the systemic immune system. COVID-19-associated liver damage is associated with direct viral cytotoxicity, activation of the systemic immune system, drug-associated liver damage, reactivation of pre-existing liver disease, and hepatitis. Most evidences suggest a relatively higher rate of COVID-19-related morbidity and mortality in cirrhotic patients. An effective and safe pharmacological treatment for cirrhotic patients with COVID-19 has not been determined. The main focus is to prevent worsening course and manage complications.

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Journal Info

Abbrev

cdk

Publisher

Subject

Health Professions

Description

Cermin Dunia Kedokteran (CDK) is a Medical Journal published since 1974 and affiliated with PT Kalbe Farma Tbk. CDK is intended to help accommodate scientific publications and help increase and disseminate knowledge related to the development of medical science, pharmacy, and public health. CDK ...