IDENTIFICATION OF COMPOUNDS IN SOURSOP LEAVES (Annona muricata L) AS BREAST ANTICANCER AGAINST ALFA ESTROGEN RECEPTORS BY MOLECULAR DOCKING

Muhammad Fauzi (Faculty of Pharmacy, “Islamic University of Kalimantan. Jl. Adhiyaksa No. 2 Kayu Tangi, Banjarmasin, Indonesia)
Nur Aini (Faculty of Pharmacy, “Islamic University of Kalimantan. Jl. Adhiyaksa No. 2 Kayu Tangi, Banjarmasin, Indonesia)
Auliana Auliana (Faculty of Pharmacy, “Islamic University of Kalimantan. Jl. Adhiyaksa No. 2 Kayu Tangi, Banjarmasin, Indonesia)
Syarifah Rugayah (Faculty of Pharmacy, “Islamic University of Kalimantan. Jl. Adhiyaksa No. 2 Kayu Tangi, Banjarmasin, Indonesia)
Ciara Fitri Pribadi (Faculty of Pharmacy, “Islamic University of Kalimantan. Jl. Adhiyaksa No. 2 Kayu Tangi, Banjarmasin, Indonesia)
Rizki Rahmadi Pratama (Faculty of Pharmacy, “Islamic University of Kalimantan. Jl. Adhiyaksa No. 2 Kayu Tangi, Banjarmasin, Indonesia)

AL-ULUM: JURNAL SAINS DAN TEKNOLOGI
Vol 10, No 2 (2024)

The incidence of breast cancer in Indonesia is steadily rising. Women have the highest incidence of breast cancer. Acetogenins are highly effective inhibitors of mitochondrial complex I or NADH dehydrogenase, making them a promising option for therapeutic creation against breast cancer. The plant known as Annona muricata, also referred to as the soursop leaf plant, is purported to possess the ability to suppress the activity of breast cancer. Hence, it is imperative to assess the chemical composition of soursop leaves on receptors by docking experiments. Research utilizing the active site on the alpha estrogen receptor has determined that the reticulin molecule, with a free energy of -8.14 kcal/mol, is a potential contender for breast cancer therapeutic medications. Reticulin exhibits the highest affinity for binding to the active site of estrogen receptor alpha. This chemical exhibits the capacity to impede the growth of breast cancer.