This study aims at evaluating the performance of Zero Inflated Negative Binomial (ZINB) regression analysis using the Maximum Likelihood Estimation (MLE) approach through simulation study. The research data used are secondary data and simulations. Secondary data was obtained from the Ministry of Health of the Republic of Indonesia in 2023 regarding cases of under-five deaths due to pneumonia with a total of 38 samples. The simulation study is conducted to analyze the performance of ZINB regression based on various sample sizes and proportions of zero values. The results show that the ZINB regression model with the MLE approach produces parameter estimates that tend to be more sensitive to sample size, with improved performance at large sample sizes. Data with a large proportion of zeros reflects high variability as well as the presence of excess zeros, so the ZINB regression model can provide more stable and precise parameter estimates than those with a lower proportion of zeros. Therefore, the ZINB regression model is effective for data with a high proportion of zeros as it fits the characteristics of the data distribution, especially in cases of under-five deaths due to pneumonia.
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