<![CDATA[Betel leaf (Pipper Betle L.) is a climbing plant that has many benefits. Betel leaves have long been used for fever therapy, cough, stomach cramps, anti-allergic, wound healing, antimicrobial, and antiproliferative. Extraction of betel leaves with green solvent requires optimization of the extraction time and percentage of betel leaves with water. Betel and propolis extracts need to be formulated to become an herbal propolis mouthwash. The purpose of this research (1). Getting the best time and percentage of betel leaves in the extraction into betel extract formulated to make herbal propolis mouthwash. (2). Getting the best formula for variations in the percentage of propolis in herbal propolis mouthwash, (3). Conduct a selectivity test to obtain the results of mouthwash as an antibiotic. Based on the results of this research with a comparison of the heating time of betel leaf extraction. Betel leaf extraction was carried out by the infusion method, and the extract was distilled with variations in the percentage of betel leaves of 2.5%, 5%, 7.5%, 10%, 12.5% , and 50% compared with water. The best heating time results for the best betel leaf extraction, based on the yield of betel leaf extraction and pH were 60 minutes. For the optimum betel leaf extraction results at a betel leaf concentration of 50%. Getting a yield value of 40% and pH 4.55 at an extraction time of 60 minutes. The research is still ongoing by conducting a test of the inhibition of Staphylococcus Aureus bacteria in herbal propolis mouthwash with variations in the percentage of propolis of 0%, 2.5%, and 5%.In the blank without the addition of propolis it does not inhibit bacteria Staphylococcus Aureus, the addition of 2.5% and 5% propolis to the herbal propolis mouthwash formula has been proven to inhibit bacteria Staphylococcus Aureus.]]>
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