Introduction: Breast cancer is the most prevalent type of cancer among women, with fatigue being one of its common side effects. This study aims to ascertain the effect of Moringa oleifera and mindfulness-based cognitive therapy on fatigue in breast cancer patients. Methods: The study used a quasi-experimental design with a total of 50 respondents, divided into an intervention group (n = 25) and a control group (n = 25), selected through simple random sampling. The study was conducted at the Bayangkara Hospital in Kediri City. The intervention group received Moringa oleifera at a dose of 500 mg twice daily for 30 days alongside mindfulness-based cognitive therapy for 8 weeks. The data were tested using a t-test with SPPS version 17. Results: Posttest results showed a significant reduction in fatigue levels in the intervention group compared to the control group (m = 1.82 SD = 1.83 vs m = 3.34 SD = 2.24), p-value 0.001. Conclusion: These findings show a combination of Moringa oleifera and MBCT is effective in reducing fatigue among breast cancer patients. The interventions are practical, non-invasive strategies that healthcare professionals can consider for improving the stamina and quality of life of breast cancer patients.
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