Medula
Vol 15 No 1 (2025): Medula

Gastroesophageal Reflux Disease-Related Asthma: Neurogenic Inflammation and Non-pharmacological Management

Wibowo, Adityo (Unknown)



Article Info

Publish Date
26 Jun 2025

Abstract

Asthma is a chronic inflammatory disease of the airways, characterized by bronchoconstriction, airway remodeling, and increased responsiveness to non-specific stimuli. While childhood-onset asthma is commonly associated with allergens, adult-onset asthma is linked to environmental and individual factors. One significant contributor to adult-onset asthma is gastroesophageal reflux disease (GERD), which exacerbates asthma symptoms through microaspiration and vagally mediated reflexes. GERD is a chronic gastrointestinal disorder characterized by acid reflux into the esophagus, influenced by factors such as obesity, tobacco use, and stress. Studies indicate a strong association between GERD and asthma, with approximately 80% of asthmatic individuals experiencing heartburn or regurgitation. GERD-induced neurogenic inflammation contributes to airway hyperreactivity and bronchospasm. Non-pharmacological interventions, including dietary modifications, weight loss, smoking cessation, and elevating the head during sleep, have shown efficacy in reducing reflux symptoms and improving asthma control.

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Journal Info

Abbrev

medula

Publisher

Subject

Education Medicine & Pharmacology Neuroscience Public Health

Description

Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 ...