Dry gambier extract obtained from gambier plants contains tannins at relatively low levels. Tannins can be obtained by extracting dry gambier using water to achieve high yields within a relatively short processing time. This study aims to analyze the interaction between extraction time and microwave power in the tannin extraction process from gambier using the microwave-assisted extraction (MAE) method to maximize tannin yield.  The research method employed was a factorial design (AxB). Factor A was extraction time, consisting of five treatments (1; 2; 3; 4; and 5 minutes) and factor B was microwave power, consisting of five variations (180W; 300W; 450W; 600W and 850W). The results showed that the gambier extraction process using MAE demonstrated an interaction between extraction time and microwave power on the yield produced, but not on the tannin content. The most optimal temperature and power that can be used is 4 minutes at 600W microwave power with a yield of 44.66%. The treatment of temperature and microwave power in the gambier extraction process showed a significant interaction with the extract yield.
                        
                        
                        
                        
                            
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