JOURNAL LA MEDIHEALTICO
Vol. 6 No. 3 (2025): Journal La Medihealtico

Diagnostic Comparison of Elevated Fecal Leukocytes and sTREM-1 in Children with Acute Diarrhea Caused by Bacterial Infection

Yudiyanto, Ade Rachmat (Unknown)
Firmansyah, Agus (Unknown)
Karyanti, Mulya Rahma (Unknown)



Article Info

Publish Date
03 Jun 2025

Abstract

Diarrhea is a health problem that most often occurs in children. Various etiologies of diarrhea can cause prolonged diarrhea and become malnourished (malnutrition). The etiology of diarrhea can be caused by a bacterial infection and requires antibiotics, so that detection is needed as early as possible. Examination of soluble triggering expressed receptors on myeloid cells-1 (sTREM-1) can predict bacterial infection in children with acute diarrhea. The study aims to know how much the diagnostic value of fecal leukocytes test compared to sTREM-1. A cross-sectional study of children aged 6-60 months with acute diarrhea without complications and other diseases. In the subjects, clinical manifestation was performed (fever, vomiting, abdominal pain), fecal leukocyte test and sTREM-1 test as a standard reference. Children, aged 6-60 months with acute diarrhea due to bacterial infections with sTREM-1 > 470 pg/mL as many as 2 of 64 subjects and fecal leukocytes > 10/HPF as many as 14 of 64 subjects, most male, normal nutritional status and had clinical manifestation of fever, vomiting and without abdominal pain. Increased fecal leukocytes > 10 / HPF has a sensitivity of 50%, specificity 79.1%, positive predictive value 7.1%, negative predictive value 98%, accuracy 78%, positive likelihood ratio 2.18 and negative likelihood ratio 0.63. Fecal leukocyte test > 10/HPF as a diagnostic confirmation is not good in diagnosing acute diarrhea due to bacterial infection.

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Journal Info

Abbrev

JournalLaMedihealtico

Publisher

Subject

Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

Description

Journal La Medihealtico is peer reviewed, open access Academic and Research Journal which publishes Original Research Articles, Review Article, Case Report editorial comments etc. in all fields of medical sciences and health sciences including Health Care Delivery, Health Care Research, ...