<![CDATA[Introduction: Parkinson's disease (PD) is a neurodegenerative disorder that significantly affects both motor and non-motor functions, leading to psychological issues such as depression and anxiety. Cognitive Behavioral Therapy (CBT) has emerged as an effective intervention for improving psychological outcomes in PD patients. This study investigates the long-term psychological and quality of life outcomes of PD patients receiving CBT. Methods: A systematic review was conducted adhering to PRISMA guidelines, focusing on studies that included adult PD patients undergoing CBT as a primary intervention. Eligible studies were screened, and data were extracted regarding study design, intervention characteristics, and outcomes related to psychological well-being and quality of life. Results: The review identified 40 studies, demonstrating that CBT significantly reduces depressive and anxiety symptoms in PD patients. Most studies reported positive changes in quality of life, particularly at 6-month follow-ups. However, the sustainability of these benefits over longer periods remains unclear, with some studies indicating diminished effects after 24 months. Discussion: While CBT shows promise in enhancing psychological health among PD patients, the variability in intervention formats and follow-up durations complicates the understanding of long-term efficacy. Factors such as intervention duration, delivery method, and individual patient characteristics may influence treatment outcomes. Conclusion: CBT is a valuable therapeutic approach for managing psychological symptoms in Parkinson's disease. However, further research is necessary to clarify the long-term effects and optimize treatment delivery, ensuring that patients receive sustained psychological support. ]]>
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