Acute Respiratory Infection (ARI) is a major public health issue in Indonesia, particularly in slum areas with poor environmental conditions. Low hygiene awareness and unhealthy living environments contribute to the high incidence of ARI, especially in large urban areas like Palembang. This quantitative study employed a cross-sectional design and involved 100 purposively selected respondents in Seberang Ulu II District, Palembang City. Data were analyzed using chi-square tests for bivariate analysis and logistic regression for multivariate analysis. The results indicated that residential density (p=0.041) and waste burning (p=0.008; OR=3.156) were significantly associated with ARI incidence. Waste management was identified as the most dominant factor (p=0.021; OR=3.156), while other variables showed no significant association. These findings highlight that residential density and waste management are key determinants of ARI. Improving household sanitation and promoting clean living behaviors are essential preventive efforts in wetland urban settlements.
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