<![CDATA[Inflammation is the body's response to tissue injury, which is usually caused by physical trauma, harmful chemicals, or microorganisms. Kencur rhizomes and bay leaves have been proven effective as anti-inflammatories. The purpose of this study is to determine the anti-inflammatory effect of a combination of kencur rhizome extract and bay leaves in reducing the volume of 1% carrageenan-induced rat foot edema. The research method is a laboratory experiment using 24 Wistar Sprague dawley male white rats with 1% carrageenan induction. The test materials used were KNR (1% carrageenan), KNT (CMC-Na 0,5%), KD1 (50 : 50 mg/kg BB), KD2 (150 : 250 mg/kg BB), KD3 (250 : 75 mg/kg BB), and KPT (diclofenac sodium) ( mg/kg BB). The test materials were administered orally one hour before induction with 0.2 mL of 1% carrageenan. Foot volume measurements were taken every hour for six hours after carrageenan induction. The results showed that the 150 : 250 mg/kg dose combination group could inhibit the onset of inflammation by 89%; the 250 : 75 mg/kg dose combination group could inhibit it by 75%; and the 50 : 50 mg/kg dose combination group could inhibit it by 56%. In the positive control group (diclofenac sodium), the percentage of inflammation inhibition was 60%. Therefore, it can be concluded that the higher the concentration of kencur rhizome extract and bay leaves, the greater the decrease in anti-inflammatory activity. The combination of kencur rhizome extract and bay leaves at a dose of 150 : 250 mg/kgBB is an effective dose for inhibiting edema, as evidenced by the results of this study.]]>
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