The research analyzed the implementation of the Global Alliance to End AIDS in Children program by UNAIDS in reducing the number of children living with HIV/AIDS in South Africa. The background of the research is based on the high prevalence of HIV/AIDS in children with gaps in access to antiretroviral therapy (ARV). The method used by the researcher is descriptive qualitative with a literature study approach and secondary data analysis from official reports, scientific journals, and international policies. The results show that through a four pillar approach of early detection, maternal and child treatment, prevention, and removal of social barriers, the program succeeded in reducing child mortality from HIV by 25% in two years. The Global Health Governance and Human Security approach is the main concept in evaluating the effectiveness of international cooperation. The findings emphasize the importance of global health governance and social inclusion in addressing HIV/AIDS in vulnerable groups.
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