<![CDATA[Accurate blood cell classification is crucial for diagnosing Acute Myeloid Leukemia (AML) but limited medical data poses challenges for traditional machine learning models. This study presents a Few-Shot Learning (FSL) framework utilizing a Prototypical Network architecture with a ResNet-34 backbone to classify AML blood cell types from microscopic images. In this study, we utilize datasets consisting of 15 morphologically distinct cell classes. A 15-way, 5-shot, 5-query episodic setup was adopted to simulate data-scarce conditions. Evaluation via 5-fold cross-validation yielded strong performance, with an average accuracy of 97.76%, precision of 98.78%, recall of 96.55%, and F1-score of 97.76%. FSL training times were consistent (4.22–4.26 minutes per fold), and t-SNE along with confusion matrices confirmed the model’s ability to distinguish similar cell types. To validate the approach, its performance was compared with a conventional supervised CNN using the same ResNet-34 backbone. The FSL model outperformed the CNN across all metrics such as accuracy (98.32% vs. 77.25%), precision (98.55% vs. 76.87%), recall (98.31% vs. 78.66%), and F1-score (98.33% vs. 75.26%), while also requiring far less training time (~4.24 min/fold vs. ~420 min total). These results highlight the promise of FSL based methods for accurate, efficient, and scalable hematologic diagnostics in data limited settings.]]>
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