Engineering Science Letter
Vol. 4 No. 02 (2025): Engineering Science Letter

Optimization of Malaria Cell Image Classification Using Pretrained Resnet50 Architecture with Data Augmentation and Fine-Tuning

Mulyani, Asri (Unknown)
Kurniadi, Dede (Unknown)
Rahmat, Agil (Unknown)



Article Info

Publish Date
31 Aug 2025

Abstract

Malaria remains a significant health concern, particularly in tropical regions such as Indonesia, where timely and accurate diagnosis is crucial for reducing transmission and mortality. Conventional diagnosis through microscopic examination is labor-intensive, time-consuming, and highly dependent on expert availability. This study proposes an automated malaria cell image classification model using a deep learning approach based on the pretrained ResNet50 architecture. The research framework adopts the SEMMA (Sample, Explore, Modify, Model, Assess) methodology to structure the development workflow. A total of 27,558 labeled blood cell images comprising two balanced classes, Parasitized and Uninfected, were used for training and evaluation. Two model configurations were tested: a baseline model without data augmentation or fine-tuning, and an optimized model that integrates both. Augmentation techniques such as rotation, flipping, shearing, zoom, and brightness adjustment were applied to increase data diversity, while fine-tuning involved unfreezing the last 20 layers of ResNet50 to adapt pretrained features to the malaria domain. Performance was evaluated using accuracy, precision, recall, F1-score, loss, and AUC-ROC. The optimized model achieved 97.63% accuracy, 0.996 AUC-ROC, and 0.2472 loss, outperforming the baseline accuracy of 92.84%. An ablation study analyzed the individual contributions of augmentation and fine-tuning, showing that both techniques play complementary roles, with fine-tuning having the greater impact. A McNemar test confirmed that the improvements were statistically significant (p < 0.05). These findings demonstrate that the optimized ResNet50 model is effective for malaria detection and holds promise for integration into real-time diagnostic systems in resource-constrained environments.

Copyrights © 2025






Journal Info

Abbrev

ESL

Publisher

Subject

Computer Science & IT Control & Systems Engineering Engineering Industrial & Manufacturing Engineering Materials Science & Nanotechnology

Description

Engineering Science Letter is an international peer-reviewed letter that welcomes short original research submissions on any branch of engineering, computer science, and technology, as well as their applications in industry, education, health, business, and other fields. Artificial intelligence, ...