High-intensity interval training was more effective than moderate-intensity interval training in lowering creatine kinase and interleukin 6 levels among sports students

Nurpratiwi, Resti
Suyoko, Andri
Rusdiawan, Afif
Ciptorini, Ariesia Dewi
Sidik, Muhammad Asrul
Lestari, Bhekti
Samudra, Fajar Eka
Triardhana, Yanuar
Pranoto, Adi
Andriana, Laily Mita
Kusuma, I Dewa Made Aryananda Wijaya
Ismalasari, Rini

Physical Therapy Journal of Indonesia
Vol. 6 No. 2 (2025): Inpress July-December 2025

Background: This study aimed to prove that high-intensity interval training (HIIT) is superior to medium-intensity continuous training (MICT) in reducing creatine kinase and interleukin 6 (IL-6) levels in sports students after 4 weeks of exercise. Methods: The study examined the effects of two different training methods—MICT and HIIT. This study included 30 students aged 19-22 years, using a pretest-posttest control group design. Participants were randomly assigned to MICT, HIIT, or control groups (no training) and trained three times a week for four weeks. Creatine and IL-6 levels were analyzed by blood sampling. Data analysis included descriptive statistics, normality tests, and ANOVA tests to evaluate group differences. Results: HIIT was found to be more effective than MICT and the control group in reducing CK and IL-6 levels in sports students after 4 weeks of training (p< 0.001). Conclusion: The HIIT and MICT reduced creatine kinase and IL-6 levels compared to the control group, but HIIT was more effective in reducing creatine kinase and IL-6 levels than MICT in sports students after 4 weeks of exercise.