The ethanol extract of Rhizophora apiculata fruit was utilized in this study with the aim of formulating it into active nanoparticles, which were then prepared in the form of a suspension dosage and evaluated for stability. The nanoparticles were produced using the ionic gelation method, followed by particle characterization using a Particle Size Analyzer (PSA) and zeta potential measurement. The characterization results showed a particle size of 126.7 ± 2.170 nm, a polydispersity index of 0.601 ± 0.1005, and a zeta potential of 34.38 ± 0.2850 mV. Overall, these findings indicate that the Rhizophora apiculata fruit extract nanoparticles are stable and suitable for further development as a suspension dosage form.
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