Ahmad Dahlan Medical Journal
Vol. 6 No. 2 (2025): November 2025

Multidimensional Clinical Challenges in a Female with Chronic Epilepsy on Phenytoin: A Case Report:

Nurulita, Syafira Laila (Unknown)
Lamsudin, Rusdi (Unknown)



Article Info

Publish Date
09 Oct 2025

Abstract

Epilepsy is a long-standing neurological disorder defined by recurrent, unprovoked seizures, affecting more than 50 million individuals globally and influencing physical, mental, and social aspects of life. Continuous administration of antiepileptic drugs (AEDs) such as phenytoin is a common therapeutic strategy; however, prolonged use may result in adverse effects that complicate treatment. This case report describes a 40-year-old woman with epilepsy since the age of four, presenting with recurrent seizures, impaired memory, headaches, and sexual dysfunction. Her most recent event was an absence seizure accompanied by upward eye deviation and tongue biting. Electroencephalography (EEG) demonstrated generalized spike-and-wave patterns. The patient was treated with phenytoin and folic acid, with the recent addition of clobazam, leading to favorable outcomes, including reduced seizure frequency, improved sleep, and diminished anxiety and dizziness. A persistent reduction in libido, first noted during adolescence, was suspected to be associated with long-term phenytoin use. Additionally, dental problems such as caries and tooth impaction were believed to worsen headache intensity. This case emphasizes the need for a comprehensive approach to epilepsy care, considering psychological conditions, cognitive impairment, and oral health. Prompt recognition of AED-related side effects and individualized treatment planning are essential to optimize patient outcomes.

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Journal Info

Abbrev

admj

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

Ahmad Dahlan Medical Journal is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health. This journal publishes original articles, ...