Genbinesia Journal of Biology
Vol. 3 No. 1 (2023): November 2023

3,3-dimethyl-octane from Physalis peruviana as promising anti-DENV via ADMET prediction of pkCSM open webserver

Prastiyanto, Muhammad Evy (Unknown)
Solekha, Rofiatun (Unknown)
Rohmah, Laila Ainur (Unknown)
Yuanita Rachmawati (Unknown)
Aini, Nur Sofiatul (Unknown)

Article Info

Publish Date
07 Jul 2024

Abstract

Dengue is caused by the dengue virus (DENV) and being prevalent in 100 tropical and subtropical countries including Indonesia. This disease is spread by Aedes mosquitoes. There is currently no clinically authorized medicine to treat the dengue fever. Physalis peruviana has ethnomedicine application and noted for its antioxidant activities. This study purpose to investigate the pharmacokinetics or ADMET of anti-DENV from leaf parts of P. peruviana. The phytoconstituents data were gathered from multiple sources. The drug property and ADMET prediction were assessed using pkCSM. Following online screening, 3,3-dimethyl-octane functioned as predictive anti-DENV therapeutic candidate. Further dry and wet lab studies are needed to validate this finding.

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Journal Info
Genbinesia Journal of Biology
Website

Abbrev

gjb

Publisher

Generasi Biologi Indonesia Foundation

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Immunology & microbiology

Description

The Genbinesia Journal of Biology particularly focuses on the core disciplines in biology, they are: astrobiology, bacteriology, behavioural science, biochemistry, biodiversity, bioethics, bioinformatics, biomathematics, biophysics, biopolymers, biostatistics, biotechnology, botany, cell biology, ...