Background: The global incidence of out-of-hospital cardiac arrest (OHCA) is a significant public health concern, though its precise rate in Indonesia remains unquantified. Cardiovascular diseases are a leading cause of mortality in Indonesia, contributing to a high burden of risk factors for OHCA. Enhancing community preparedness through basic life support (BLS) training is a critical strategy to improve survival rates. Objective: This study aimed to evaluate the impact of a BLS training program on the knowledge and practical skills of students at SMAN 1 Sungai Ambawang in managing cardiac arrest. Methods: A single-group, pre-test-post-test study design was employed. Participants' knowledge and skills were assessed immediately before and after a structured BLS training session. The Wilcoxon signed-rank test was used to analyze the differences in median scores, with a significance level of α < 0.05. Results: A total of 50 students participated. The median knowledge score increased from 63.66 (pre-test) to 86.50 (post-test). The median practical skills score demonstrated a more substantial improvement, rising from 36.00 to 94.06. The statistical analysis confirmed that these improvements were significant for both knowledge (p=0.001) and skills (p=0.001). Conclusion: A single session of BLS training significantly improved the knowledge and practical skills of high school students in cardiac arrest management. Implementing such training in school curricula is recommended to empower the lay public as potential first responders, thereby strengthening the chain of survival for OHCA victims in the community
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