Jurnal Klinik dan Riset Kesehatan
Vol 5 No 1 (2025): Edisi Oktober 2025

Analisis Activated Clotting Time pada Intervensi Koroner Perkutan Elektif dengan Heparin Bolus dan Kontinu di RSUD Dr. Saiful Anwar Malang

Suprapta, Aloysius (Unknown)
Widito, Sasmojo (Unknown)



Article Info

Publish Date
31 Oct 2025

Abstract

BACKGROUND: Unfractionated heparin effectively prevents thrombosis during percutaneous coronary intervention (IKP). Analysis between sex, age, BMI, diabetes, smoking, CHF, hypertension, stroke, lesion characteristics, CHA2DS2-VASc score, platelet, eGFR, and bleeding events with activated clotting time (ACT) achievement aims to elucidate the correlation in elective IKP procedures using heparin bolus administration followed by continuous heparin. OBJECTIVE: To evaluate the relationship of sex, age, BMI, diabetes, smoking, CHF, hypertension, stroke, lesion characteristics, CHA2DS2-VASc score, platelet, eGFR, and bleeding events on achieving an ACT of ≥300 seconds in elective IKP patients at RSSA. METHODS: This observational study analysed medical records of elective IKP patients at RSSA from July 2022 to August 2024. Data were collected via consecutive sampling. Univariate analysis described sample characteristics, while bivariate analysis assessed variable relationships. Logistic regression was used to develop a predictive model if significant variables was found. RESULTS: Among 43 samples, 34.8% achieved ACT ≥300 seconds. No significant relationship was found among sex, age, BMI, diabetes, smoking, CHF, hypertension, stroke, lesion characteristics, CHA2DS2-VASc score, platelet, and eGFR (p=0.078; p=0.936; p=0.264; p=0.139; p=0.063; p=0.535; p=0.64; p=0.324; p=0.349: p=0.885; p=0.677; p=0.15 respectively). There is no bleeding event after procedure. CONCLUSION: There is no relationship between variables sex, age, BMI, diabetes, smoking, CHF, hypertension, stroke, lesion characteristics, CHA2DS2-VASc score, platelet, and eGFR to ACT achievement in elective IKP patients receiving bolus and continuous heparin. Further research with larger sample sizes and standardized ACT measurements is recommended.

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Journal Info

Abbrev

jk-risk

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

Description

Jurnal Klinik dan Riset Kesehatan (JK-RISK) – RSUD dr. Saiful Anwar Malang adalah jurnal open-access resmi yang dikelola oleh tim Penelitian dan Pendidikan Rumah Sakit Umum Daerah dr. Saiful Anwar Malang, Jawa Timur, Indonesia. JK-RISK menerbitkan satu volume yang terdiri atas tiga nomor setiap ...