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Suprapta, Aloysius
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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CPET : Gambaran Umum dan Penggunaan pada Pasien Gagal Jantung Suprapta, Aloysius; Listyoko, Aditya; Djajalaksana, Susanthy
Jurnal Klinik dan Riset Kesehatan Vol 1 No 2 (2022): Edisi Februari
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1191.19 KB) | DOI: 10.11594/jk-risk.01.2.5

Abstract

Cardiopulmonary exercise test (CPET) is a non-invasive modality used to assess a person's exercise capacity. An assessment of the gas exchange mechanism that occurs in the breath-to-breath stage of respiration will describe gas exchange at the cellular level. Monitoring of gas exchange is a parameter in assessing abnormalities that cause disruption of aerobic metabolic processes in the body. These parameters in CPET assist clinicians in sorting and assessing the factors that cause dyspnea or fatigue during activity, whether disorders on the respiratory system, cardiovascular system, or muskuloskeletal side. In addition, CPET is also a modality in determining the prognosis and feasibility of heart transplantation in clients with heart failure. Peak VO2 assessment 14 mL/kg/min gave a better picture of cumulative survival in heart failure patients, and O2 pulse 10 mL/beat showed better event-free survival.
CPET : Gambaran Umum dan Penggunaan pada Pasien Gagal Jantung Suprapta, Aloysius; Listyoko, Aditya; Djajalaksana, Susanthy
Jurnal Klinik dan Riset Kesehatan Vol 1 No 2 (2022): Edisi Februari
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.01.2.5

Abstract

Cardiopulmonary exercise test (CPET) is a non-invasive modality used to assess a person's exercise capacity. An assessment of the gas exchange mechanism that occurs in the breath-to-breath stage of respiration will describe gas exchange at the cellular level. Monitoring of gas exchange is a parameter in assessing abnormalities that cause disruption of aerobic metabolic processes in the body. These parameters in CPET assist clinicians in sorting and assessing the factors that cause dyspnea or fatigue during activity, whether disorders on the respiratory system, cardiovascular system, or muskuloskeletal side. In addition, CPET is also a modality in determining the prognosis and feasibility of heart transplantation in clients with heart failure. Peak VO2 assessment 14 mL/kg/min gave a better picture of cumulative survival in heart failure patients, and O2 pulse 10 mL/beat showed better event-free survival.
Antikoagulan Parenteral Pada Intervensi Koroner Perkutan: Mekanisme Kerja, Monitoring, dan Faktor-Faktor yang Memengaruhi Suprapta, Aloysius; Widito, Sasmojo
Jurnal Klinik dan Riset Kesehatan Vol 4 No 3 (2025): Volume 4 No 3, Juni 2025
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.04.3.7

Abstract

Background: The increasing number of heart attacks also followed by increases percutaneous coronary intervention (PCI). Coronary heart disease and PCI itself will increase the incidence of thrombosis in the coronary blood vessels. The use of parenteral anticoagulants and antiplatelets is necessary before, during and after PCI. Objective: Appropriate use of anticoagulants will provide expected benefits and avoid side effects such as bleeding. Accurate use of anticoagulants requires understanding the mechanism of action, monitoring drug consentration, and considering factors that influence the mechanism of action of anticoagulants. Discussion: There are three anticoagulants commonly used in Indonesia, namely unfractionated heparin, low molecular weight heparin (LMWH), and fondaparinux. These three anticoagulants affect the coagulation process by inhibiting thrombin formation. The profile of each anticoagulant has unique characteristics with heparin as an anticoagulant that is often used and easily available in health facilities, but has different reactions in each person, therefore requires regular monitoring. LMWH and fondaparinux have a more stable reaction so rarely require monitoring. Conclusion: Parenteral anticoagulants are useful in preventing the occurrence of thrombi before and during PCI procedures. Giving the right dose will reduce the effects of bleeding. Unfractionated heparin is an anticoagulant that often be used and available in health facilities but requires regular monitoring. Several factors can influence the mechanism of action of anticoagulants such as gender, body weight, kidney function, platelet count, smoking, and diabetes.
Analisis Activated Clotting Time pada Intervensi Koroner Perkutan Elektif dengan Heparin Bolus dan Kontinu di RSUD Dr. Saiful Anwar Malang Suprapta, Aloysius; Widito, Sasmojo
Jurnal Klinik dan Riset Kesehatan Vol 5 No 1 (2025): Edisi Oktober 2025
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.05.1.4

Abstract

BACKGROUND: Unfractionated heparin effectively prevents thrombosis during percutaneous coronary intervention (IKP). Analysis between sex, age, BMI, diabetes, smoking, CHF, hypertension, stroke, lesion characteristics, CHA2DS2-VASc score, platelet, eGFR, and bleeding events with activated clotting time (ACT) achievement aims to elucidate the correlation in elective IKP procedures using heparin bolus administration followed by continuous heparin. OBJECTIVE: To evaluate the relationship of sex, age, BMI, diabetes, smoking, CHF, hypertension, stroke, lesion characteristics, CHA2DS2-VASc score, platelet, eGFR, and bleeding events on achieving an ACT of ≥300 seconds in elective IKP patients at RSSA. METHODS: This observational study analysed medical records of elective IKP patients at RSSA from July 2022 to August 2024. Data were collected via consecutive sampling. Univariate analysis described sample characteristics, while bivariate analysis assessed variable relationships. Logistic regression was used to develop a predictive model if significant variables was found. RESULTS: Among 43 samples, 34.8% achieved ACT ≥300 seconds. No significant relationship was found among sex, age, BMI, diabetes, smoking, CHF, hypertension, stroke, lesion characteristics, CHA2DS2-VASc score, platelet, and eGFR (p=0.078; p=0.936; p=0.264; p=0.139; p=0.063; p=0.535; p=0.64; p=0.324; p=0.349: p=0.885; p=0.677; p=0.15 respectively). There is no bleeding event after procedure. CONCLUSION: There is no relationship between variables sex, age, BMI, diabetes, smoking, CHF, hypertension, stroke, lesion characteristics, CHA2DS2-VASc score, platelet, and eGFR to ACT achievement in elective IKP patients receiving bolus and continuous heparin. Further research with larger sample sizes and standardized ACT measurements is recommended.
Co-Authors Djajalaksana, Susanthy Listyoko, Aditya Widito, Sasmojo