Hydrogen: Jurnal Kependidikan Kimia
Vol. 12 No. 2 (2024): April-May 2024

Analysis of Ranitidine Hydrochloride Content in Drug X Samples Using A UV-Visible Spectrophotometry

Rosmainar, Lilis (Unknown)
Yanwerico, Manuel (Unknown)



Article Info

Publish Date
30 Apr 2024

Abstract

The development and progress of modern society cannot be separated from the availability of health medicines. Conventional medicinal products such as capsules and tablets are formulated to release active compounds immediately after consumption. Tablets are solid drug dosage forms consisting of one or more medicinal ingredients. One type of solid drug dosage form is ranitidine hydrochloride. Ranitidine hydrochloride belongs to a class of antagonist drugs that attack histamine H receptors2 selectively and reversibly by reducing the process of secretion by gastric acid which is widely used for the treatment of stomach ulcers, intestinal ulcers (duodenum ulcers), Zollinger-Ellison syndrome, Gastro Esophageal Reflux Disease (GERD) and esophageal erosion. Determination of ranitidine hydrochloride levels was carried out using an ultraviolet spectrophotometer validation method with maximum absorption at a wavelength of ±314 nm. In UV spectrophotometer analysis, peaks were detected at wave number 313.80 nm with absorbance values of 0.425, 0.416, 0.421, 0.424, 0.413, and 0.418. The concentration results obtained for each sample were sample I 119.22%, sample II 116.70%, sample III 118.10%, sample IV 118.94%, sample V 115.85%, and sample VI 117.26% which fulfilled the requirements.

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Journal Info

Abbrev

hydrogen

Publisher

Subject

Chemistry Education

Description

Hydrogen: The Chemistry Education Journal published by the Chemistry Education Study Program which contains articles raised from the results of conceptual research and studies in chemistry and chemistry education including education and learning, device development, media and learning ...