<![CDATA[Mesenchymal stem cells (MSC) associated with anti-inflammatory, immunomodulatory, regenerative, pro-angiogenic, and anti-fibrotic properties offers a novel therapeutic approach for fibrosis lung disease. Such therapeutic effects may be attributed to the MSC-secretome, made from free soluble proteins and extracellular vesicles (EVs). This review summarizes some literature findings related to the efficacy and safety of MSC-derived products in pre-clinical models of lung diseases, demonstrating the biologically active substances contained in the MSC-secretome and its mechanisms involved in tissue regeneration. A perspective view is given on the secretome as a high-quality, safe, and effectivemedicinal product.]]>
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