This study aims to determine the clustering results and characteristics of districts or cities in Southeast Sulawesi Province based on infectious disease cases in 2022 using the Fuzzy C-Means (FCM) algorithm. The analysis used the standard deviation ratio as a cluster validity measure. The clustering process produced five clusters. Cluster 1 consists of Kendari City which is characterized by a very high number of infectious disease cases. Cluster 2 includes Buton, Konawe, Bombana, North Kolaka and Baubau City which are characterized by low case numbers. Cluster 3 consists of Kolaka and South Konawe both of which have high numbers of cases. Cluster 4 includes Wakatobi, North Buton, North Konawe, East Kolaka, Konawe Islands, West Muna, Central Buton and South Buton which are characterized by very low numbers of cases. Cluster 5 consists of Muna District which is characterized by a moderately high number of infectious disease cases. These results indicate that the FCM method performs well in identifying patterns of disease spread across the region.
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