The Effect of Ethanol Extract of Jicama (Pachyrhizus erosus) on Apoptosis Index and Endometrial Thickness in White Rats (Rattus norvegicus) Ovariectomy Model

Meirna Eka Fitriasnani
Mayasari Putri Ardela
Clara Anabel Galla
Ayu Tiska Arlik Insiati

Strada Jurnal Ilmiah Kesehatan (SJIK)
Vol. 14 No. 2 (2025): November

Menopause is the permanent cessation of menstruation due to the loss of ovarian follicular activity, which marks the end of a woman's reproductive function. During menopause, estrogen levels decrease, triggering oxidative stress, leading to cell death (apoptosis) and a decrease in endometrial thickness, which can lead to symptoms such as hot flushes, sleep disturbances, decreased sexual desire, and changes in the menstrual cycle. Menopause-related symptoms are considered natural and are often ignored because they are related to a woman's menstrual cycle. Menopause-related problems increase morbidity and mortality due to inadequate treatment, so interventions are needed to reduce morbidity by alleviating symptoms during menopause.