Abstract: The phenomenon of a sedentary lifestyle is increasing, coinciding with the growing dominance of technology-based activities in academic environments. At Makassar State University, lecturers and educational staff spend most of their working time sitting, increasing the risk of health problems. This study aims to design a physical activity model based on the Isotemporal Substitution Model (ISM) as a preventive measure against sedentary behaviour. The method used is Design Science Research Method (DSRM), which includes stages of problem identification, requirements formulation, artefact design, demonstration, and evaluation. The results indicate that the developed artefact—a model for substituting sitting time with various categories of physical activity (moderate, vigorous, very vigorous aerobic activity, and muscle strengthening)—can be adaptively applied by lecturers and educational staff according to work conditions and available time. The implementation of this model is recommended to be supported by institutional policies and institutional health programs to ensure sustainability and provide a long-term, positive impact on the quality of life of the academic community. Keywords: Isotemporal Substitution Model, physical activity, sedentary behaviour, DSRM, UNM
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