Antibiotic resistance is a global threat that contributes to rising morbidity, mortality, and healthcare costs. Public education is a key strategy to curb resistance, particularly among the younger generation. This community service activity was carried out through a campaign on the prudent use of antibiotics at SMAN 1 Sungai Apit, Riau, involving students from grade 12 MIPA 1–4. The methods included interactive lectures, discussions, and pre-test and post-test evaluations. The results showed a significant increase in students’ knowledge regarding rational antibiotic use. These findings highlight the importance of public education, media involvement, and health system reform.
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