In Vivo Antihyperlipidemic Activity of TD.HLM01 – A Vietnamese Traditional Remedy in Experimental Models

Tung Thanh Tran (Hanoi Medical University, Hanoi)
Ha Thi Thu Nguyen (Hanoi Medical University, Hanoi)
Thuy Thanh Nguyen (Hanoi Medical University, Hanoi)
Lien Huong Thi Nguyen (Sao Thai Duong Joint Stock Company, Hanoi)
Van Hong Thi Nguyen (Sao Thai Duong Joint Stock Company, Hanoi)
Hang Thi Thuy Nguyen (Hanoi Medical University, Hanoi)
Quang Vinh Trinh (Hanoi Medical University, Hanoi)
Hang Thi Thu Dinh (Hanoi Medical University, Hanoi)
Duong Thuy Dau (Hanoi Medical University, Hanoi)
Phong Xuan Pham (Military Institute of Traditional Medicine, Hanoi)
Nghia Trong Duong (National Hospital of Traditional Medicine, Hanoi)
Van Anh Thi Pham (Hanoi Medical University, Hanoi)

Majalah Obat Tradisional
Vol 30, No 3 (2025)

One of the primary risk factors for cardiovascular disease nowadays is dyslipidemia. For many years, multi-herbal preparations have been the standard treatment approach for treating dyslipidemia. The purpose of this study was to assess the effects of TD.HLM01 hard capsule on experimental rodent models of endogenous and exogenous dyslipidemia. To create hyperlipidemia in the endogenous hyperlipidemia paradigm, mice were first given TD.HLM01 hard capsule therapy and intraperitoneal injections of poloxamer-407. In the exogenous model, rats were given a diet of oil-cholesterol mixture orally and treated with TD.HLM01 hard capsules for four consecutive weeks. Serum lipid parameters were evaluated in both experiments. The results indicated that TD.HLM01 significantly reduced TC, TG, and non-HDL-C levels in the experimental models of exogenous hyperlipidemia and endogenous hyperlipidemia. TD.HLM01 improved the serum LDH levels and ameliorated the elevated AST and ALT levels in cholesterol-induced hyperlipidemia rats. This study has demonstrated the potential efficacy of TD.HLM01 in hyperlipidemia experimental models in vivo.