This study evaluates the performance of the DenseNet121 architecture for binary classification of breast cancer histopathological images using the BreakHis dataset. The model employs ImageNet pre-trained weights, fine-tuning, and geometric data augmentation to improve feature learning and generalization. To obtain more reliable results, three optimization algorithms (Adam, AdamW, and RMSprop) were evaluated through repeated experiments, and performance was reported using mean and standard deviation of test metrics. The experimental results demonstrate that DenseNet121 achieves consistently high classification performance across different optimizers, with the Adam optimizer showing the most stable results. These findings indicate that DenseNet121 combined with data augmentation provides an effective and robust approach for histopathological image classification while emphasizing the importance of repeated evaluation for reliable performance assessment.
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