<![CDATA[Background: Ingredients that have a role as fragrance and flavoring in toothpaste have the potential to cause allergies and irritation to the body, especially to the mucous tissue in the mouth. Diseases of the oral mucosa are very common: recurrent aphthous stomatitis (recurrent oral ulceration) affects 20% of the population. Therefore, allergenic substances such as anethole toothpaste on the patient's oral symptoms (stomatitis, glossitis, gingivitis, buccal mucositis, burning, pain, and possibly burning mouth syndrome and recurrent aphthous ulcers) are unclear and should be further investigated. Purpose: To investigate and provide further explanation of our body's xenobiotic metabolic reactions to anethole. Method: We collected and analyzed several research journal articles related to the effects of anethole compounds. Results: The majority of articles indicated the role of the tiny anethole as an allergen. The dose of anethole which is generally contained in toothpaste normally is really low so that within an average of 72 hours it is likely to have been completely eliminated from the body's system. Conclusion: Claims of anethole compound C10H12O as a cause of irritation or inflammation are inaccurate and considered too explicit as the main factor causing allergies. Keywords: Allergen; Anethole; Metabolism; Toothpaste; Xenobiotic.]]>
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