OPTIMASI VARIASI KONSENTRASI TWEEN 80 PADA FORMULASI NANOEMULSI KOMBINASI EKSTRAK DAUN PEGAGAN DAN DAUN KELOR

lahardo, devanus
Pradikatama Prihantono, yafet

Unesa Journal of Chemistry
Vol. 14 No. 3 (2025): Vol 14 No 3 (2025) (on progress)

Abstract. This study aims to optimize the nanoemulsion formulation of combined extracts of Centella asiatica and Moringa oleifera leaves using varying concentrations of Tween 80 as a surfactant. Three formulas were prepared with 8%, 10%, and 12% Tween 80. Physical evaluations included particle size, pH, and viscosity. Results showed that increasing Tween 80 concentration increased particle size and viscosity, while pH remained relatively stable. The 8% Tween 80 formula yielded the most optimal result with the smallest particle size and suitable viscosity for topical application. One-way ANOVA revealed significant differences in particle size and viscosity, but not in pH. These findings indicate that Tween 80 concentration affects the physical stability of the nanoemulsion Key words: kelor leaves, pegagan leaves, nanoemulsion, tween 80