<![CDATA[Eugenol and its derivatives, phenylpropanoid compounds derived from plants like Syzygium aromaticum, exhibit significant biological activities, including antimicrobial, antifungal, anti-inflammatory, antioxidant, analgesic, and anticancer properties. These attributes make them valuable in drug development and medical applications. In mathematical chemistry, chemical topology graphs are used to determine the topological indices of molecules, which to help predict physical and chemical properties. Here, atoms are represented as nodes and bonds as edges. This study explores the relationship between the Sombor index, the reduced Sombor index, and the boiling points of eugenol and its derivatives. The methodology includes literature review and computational analysis of the indices, followed by correlation analysis with the boiling points. The findings reveal that the Sombor index negatively correlates with the boiling point, explains 84.8% of the boiling point variance. This implies that an increase in the Sombor index results in a lower boiling point. Conversely, the reduced Sombor index demonstrates a positive correlation, influencing 36.1% of the boiling point variations, indicating that higher reduced Sombor indices correspond to higher boiling points. When combined, the Sombor and reduced Sombor indices explain 86.4% of the boiling point variance, highlighting their significance as predictive parameters. These results provide insights into the thermal properties of eugenol-based compounds and their potential applications in material and pharmaceutical sciences. By leveraging these indices, researchers can better predict and tailor the physical properties of eugenol derivatives for specific purposes.]]>
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