Majalah Obat Tradisional
Vol 19, No 3 (2014)

EFEK HEPATOPROTEKTIF DAN NEFROPROTEKTIF BIJI ALPUKAT PADA TIKUS TERINDUKSI KARBON TETRAKLORIDA

Phebe Hendra (Faculty of Pharmacy, Universitas Sanata Dharma)
Gidion Krisnadi (Faculty of Pharmacy, Universitas Sanata Dharma)
Ni Luh Putu Dian Perwita (Faculty of Pharmacy, Universitas Sanata Dharma)
Ike Kumalasari (Faculty of Pharmacy, Universitas Sanata Dharma)
Yuditha Anggarhani Quraisyin (Faculty of Pharmacy, Universitas Sanata Dharma)



Article Info

Publish Date
14 Dec 2015

Abstract

The aim of this research to investigate the hepatoprotective and nephroprotecitve effects of Avocado seeds against carbon tetrachloride in rats. The rats was treated with the infusion and decoction of avocado seeds at doses 360.7, 642.1, 1142,9 mg/kg per oral once in a day for 6 days and carbon tetrachloride (2mL/kg) was given on the 7th day. Blood sample from all groups was obtained by sinus orbitalis after 24 hours application for the serum transaminase and creatinine. The increasing of serum transaminase and creatinine in carbon tetrachloride-treated rats, were significantly decreased (p<0.05) with both pretreatment of infusion and decoction of avocado seeds. Based on the research, it can be concluded that infusion and decoction of avocado seeds have a potent protective action upon carbon tetrachloride-induced hepatic and renal damage in rats.

Copyrights © 2014






Journal Info

Abbrev

TradMedJ

Publisher

Subject

Health Professions Medicine & Pharmacology Public Health

Description

raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, ...