This research aims to investigate the relationship between e-cigarette use, propylene glycol content, and the FEV1/FVC ratio in women aged 17–25 years in South Jakarta, as well as to analyze the findings from an Islamic health ethics perspective. A cross-sectional analytical study was conducted involving 40 female e-cigarette users aged 17–25 years in South Jakarta. Data were collected using spirometry to measure FEV1 and FVC, and a structured questionnaire to assess e-cigarette usage patterns and PG exposure. Purposive sampling was applied, and data were analyzed using descriptive and correlational statistics. All respondents showed FEV1/FVC ratios within normal limits (>75%), with no significant correlation found between the duration or intensity of e-cigarette use and lung function decline. Variations in usage patterns (puffs per day, liquid consumption) did not demonstrate a clear association with FEV1/FVC outcomes. Additionally, no meaningful relationship was observed between e-cigarette use and menstrual pain history. Although e-cigarette use among young women in this sample did not show immediate adverse effects on lung function as measured by FEV1/FVC, potential long-term risks remain a concern. From an Islamic perspective, e-cigarette use may be considered makruh or even haram if proven harmful to health, aligning with the principle of preserving well-being (hifz al-nafs) and avoiding harm (darar). These findings highlight the need for continuous health monitoring and religiously informed public health messaging regarding e-cigarette use.
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