Potential of the Ethyl Acetate Extract of Kesambi (Schleichera oleosa) Bark as an Ointment-Based Treatment for Skin Diseases Against Staphylococcus aureus

Juliandoz (Department of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Jl. KH. Wasyid No. 06, Wetan, Sukmajaya, Jombang District, Cilegon City, 42411, Banten, Indonesia.)
Dzulhijar (Department of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Jl. KH. Wasyid No. 06, Wetan, Sukmajaya, Jombang District, Cilegon City, 42411, Banten, Indonesia.)
Sekar Ayu Ningrum (1. Department of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Jl. KH. Wasyid No. 06, Wetan, Sukmajaya, Jombang District, Cilegon City, 42411, Banten, Indonesia. 2. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas N)
Boima Situmeang (Department of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Jl. KH. Wasyid No. 06, Wetan, Sukmajaya, Jombang District, Cilegon City, 42411, Banten, Indonesia.)
Nani Yulianti (Department of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Jl. KH. Wasyid No. 06, Wetan, Sukmajaya, Jombang District, Cilegon City, 42411, Banten, Indonesia.)
Nurhayati Bilangi (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Gorontalo, Jl. Jend. Sudirman No. 6, Dulalowo Timur, Kota Tengah District, Gorontalo City, 96128, Gorontalo, Indonesia.)
Weny Junus Abdul Musa (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Gorontalo, Jl. Jend. Sudirman No. 6, Dulalowo Timur, Kota Tengah District, Gorontalo City, 96128, Gorontalo, Indonesia.)
Mervina Rondonuwu (⁠Department of Pharmacy, Faculty of Science and Technology, Universitas Prisma, Jl. Pomorouw No. 113, Tikala Baru, Tikala District, Manado City, North Sulawesi, Indonesia.)

Jurnal Riset Sains dan Kimia Terapan
Vol. 11 No. 2 (2025): Jurnal Riset Sains dan Kimia Terapan, Volume 11 Nomor 2, Desember 2025

One plant with potential to treat skin diseases is the Kesambi plant. Based on community experience in Cilegon, a decoction of Kesambi tree bark has been used to treat skin ailments, including itching, insect bites, and scabies. This research aims to reveal the potential of ethyl acetate extract from the tree bark as a standardized ointment preparation. Extraction was performed using the maceration method. Quality testing of the ointment included antibacterial, safety, stability, organoleptic, and bioactive compound content testing. The best formulation was formulation 1, with an antibacterial inhibition zone of 0.6-0.7 mm, classified as moderate. Increasing the amount of extract did not significantly affect antibacterial activity. The bioactive compound content in the ointment consisted of compounds from the groups of triterpenoids, steroids, phenolics, and flavonoids.