The double burden in the development of Indonesia’s health sector consists of communicable diseases and degenerative diseases. Communicable diseases are difficult to eradicate because their transmission is not limited by administrative boundaries. One of the most cost-effective preventive measures to limit the spread of diseases to other regions is immunization. The aim of this study was to determine the effectiveness of an immunization education intervention on mothers’ knowledge regarding complete basic immunization in Lubuk Siam Village. This research employed a quantitative approach using a quasi-experimental design with a one-group pre-test–post-test method. The study population consisted of 152 mothers with children under five, from which 30 respondents were selected as the sample. The results showed a significant difference in knowledge between pre-test and post-test scores, with a statistical test result of p = 0.015. The Wilcoxon test indicated that the educational intervention was effective in improving mothers’ knowledge about complete basic immunization. It is recommended that Lubuk Siam Village integrate immunization education into routine posyandu (integrated health post) programs and involve community leaders as well as local government in supporting the sustainability of the immunization program.
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