Physical Characterization and Dissolution Study of Pentagamavunon-0 Loaded Self Nano-Emulsifying Drug Delivery System

Astuti, Ika Yuni (Universitas Muhammadiyah Purwokerto)
Marchaban, Marchaban (Universitas Gadjah Mada)
Martien, Ronny (Universitas Gadjah Mada)
Nugroho, Agung Endro (Universitas Gadjah Mada)

INDONESIAN JOURNAL OF PHARMACY
Vol 29 No 2, 2018

The recent work focuses on the physical characterization and dissolution study of PGV-0 loaded self-nanoemulsifying drug delivery system (SNEDDS). The PGV-0 SNEDDS was prepared by spontaneous emulsification method using oleic acid, tween 20:labrasol (1:1) and polyethylene  glycol  400. The zeta potential of the PGV-0 SNEDDS was   -34.4 ± 7.66 mv. The nanoemulsion of PGV-0 SNEDDS was thermodynamically stable with forming droplet oil containing PGV-0 in it and spherical. The dissolution result showed that the PGV-0 SNEDDS was able to increase the dissolution significantly (p <0.05) compared with PGV-0 powder of 44.13% in AGF medium and 30.37% in AIF medium. It is concluded that SNEDDS PGV-0 was able to increase the PGV-0 aqueous solubility.