<![CDATA[Background: Hyperglycemia is a pathological condition characterized by fasting blood glucose levels exceeding 100 mg/dL, leading to increased production of free radicals and reduced activity of endogenous antioxidant enzymes such as glutathione peroxidase (GSH-Px). Oxidative stress plays a crucial role in the progression of diabetes complications. Galoba fruit (Hornstedtia sp.) is a traditional herbal plant rich in flavonoids, recognized for its antioxidant properties. These characteristics mark the potential of the plant as a complementary therapy in reducing oxidative stress in hyperglycemia. Objective: This study aimed to evaluate the effect of galoba fruit tea on GSH-Px enzyme activity in the serum of hyperglycemic mice. Materials and Methods: This study used post-test-only control group design. As many as 24 male Balb/C mice were divided into six groups: KN (normal control), K− (negative control), K+ (positive control, receiving metformin 1.3 mg/kg BW), and three treatment groups receiving galoba fruit tea at doses of 100 mg/kg BW (P1), 200 mg/kg BW (P2), and 300 mg/kg BW (P3). Hyperglycemia was induced with multiple low doses of streptozotocin (40 mg/kg BW) for 5 days. We collected serum on day 22, and measured GSH-Px activity using a UV–Vis Spectrophotometer at 412 nm. Results: Administration of galoba fruit tea increased GSH-Px activity, with the highest mean value observed in the P1 group (38.08 U/mL), followed by P2 (36.11 U/mL) and P3 (20.74 U/mL). However, these differences were not statistically significant (p > 0.05). Conclusion: Galoba fruit tea exhibits potential in enhancing GSH-Px enzyme activity in hyperglycemic mice, particularly at lower doses (100 mg/kg BW). This potential has demonstrated that galoba fruit tea can support endogenous antioxidant defense mechanisms as a complementary strategy to manage hyperglycemia. Therefore, this study suggests optimizing dosage and evaluating long-term effects of the galoba fruit tea for further studies.]]>
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