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Majalah Biomorfologi (Biomorphology Journal)

MBIO
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Published by Universitas Airlangga

ISSN : 02158833 EISSN : 27160920 DOI : 10.20473/mbiom.v30i1.2020.1-7

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

Majalah Biomorfologi publishes articles in the form of original research report, excel-literature review, communication and special case report. The scope of this journal includes Medicine and Health sciences, focusing in basic and applied Anatomy and Histology (i.e., neuroscience, medical and health education, anthropology, clinical genetics, embryology, medical education, clinical anatomy, histotechnics, and photomicroscopy) although other correlated topics are also welcomed.

Arjuna Subject : Kedokteran - Anatomi

Articles 116 Documents

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EFFECTS OF LOW DOSE EXPOSURE OF BORAX FOR 8 WEEKS ON GASTRIC ULCER FORMATION Audi Salman Faza; Linda Dewanti; Ema Qurnianingsih
Majalah Biomorfologi Vol. 30 No. 1 (2020): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: Borax, a carcinogenic toxicant, is illegally used as food additives frequently. Previous researches shown that high dose of borax exposure (300 mg/kg of BW) caused gastric ulcer, but low dose of borax, as found as usual dose in food, has not been frequently researched. Objective: The aim of this study was to analyze the effects of low dose of borax for 8 weeks on the formation of gastric ulcer. Materials and Methods: Twenty four young adult rats (Rattus norvegicus) were divided into 4 groups (Control, Group 1, 2, and 3). Borax doses of 50 mg/kg, 150 mg/kg, and 300 mg/kg were administered on groups 1, 2, and 3 respectively through sonde for 8 weeks; Control group was not exposed with borax. Body weight was monitored every 2 weeks. On the last day of the experiment, rats were euthanized and gastric ulcers were histopathologically analyzed using a microscope. The data were analyzed by the comparative test of Mann-Whitney and the significancy was set on p<0.050. Results: The results showed that body weight was significantly different on the 6th week between Control vs Group 1 (p=0.010) and Control vs Group 3 (p=0.043). The grade of gastric ulcer was found higher in Group 2 and Group 3 compared to Control (p=0.019 and 0.011 respectively). Conclusion: Both of low dose (150 mg/kg BW) and high dose (300mg/kg BW) of borax exposure for 8 weeks cause microscopic gastric ulcer on rats.

KARAKTERISTIK PASIEN TUBERKULOSIS TULANG BELAKANG DI RSUD DR. SOETOMO SURABAYA Amy Rosalie Sukamto; Primadenny Ariesa Airlangga; Tri Hartini Yuliawati
Majalah Biomorfologi Vol. 29 No. 1 (2019): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: Spine tuberculosis or spondylitis TB is one of the most common found extrapulmonary form of Mycobacterium tuberculosis infection that can be rapidly transmitted. However, people’s alertness are still to be increased and this disease is still rarely investigated. Objective: To study the characteristics of spondylitis tuberculosis patients to enhance the understanding of the disease and improve alertness to its signs and symptoms. Material and method: This study was conducted by assessing patients’ medical records based on particularly the epidemiology, signs and symptoms, radiology and laboratory tests. Collected data were assessed retrospectively and analyzed descriptively. Results: Of 35 patients, most come from early adult age group which is ranged from 26 to 35 years old (25.72%), and 57.14% of the patients were female. Sorted from the most to least common found signs and symptoms are back pain (85.71%), formation of abscess (74.29%), formation of gibbus (54.29%), fever (37.14%), and significant weight loss (34.29%). In radiologic evaluation, spine destruction were found on 82.86% of the patients. Erythrocyte sedimentation rate (ESR) was evaluated from 30 patients, 90% of which had increased ESR to >30 mm/hour. The leukocyte count was based from 35 patients, which result was 71.43% of them had normal count. Conclusions: Spondylitis TB is mostly found in adult females with back pain as the most common symptom. Most patients had spine destruction. Largely had elevated ESR while their leukocyte count mostly remains within normal range.

EVALUASI JARINGAN DALAM STUDI IN VIVO PEMBERIAN EKSTRAK PROPOLIS PADA MODEL LUKA INFEKSI Winona May Hendrata; Willy Sandhika; Agung Dwi Wahyu Widodo
Majalah Biomorfologi Vol. 29 No. 2 (2019): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: Infection in wound could lead to various consequences including scarring and occurrence of sepsis. With increasing prevalence of resistant strain bacteria, option for treating infected wound need to be constantly expanded. Propolis, a product of honey bee, is a potential treatment which has been studied to have various effects including antibacterial, anti-inflammatory, and antioxidant. Objective: The study aims to assess the effect of propolis toward wound healing, by evaluating wound macroscopic and microscopic appearance. Material and method: Propolis extract were made using maceration technique using ethanol. Thirty Rattus norvegicus male rats were divided into six groups: three groups for treatment and three groups for control. Incision wound were made in the back and was infected with Methicillin ResistantStaphylococcus aureus (MRSA). Propolis was administered orally on daily basis. Wound excision for observation were done on day3, 5, and 7. The tissue were processed using haematoxylin-eosin (HE) staining for microscopic observation. The distance of normal tissue surrounding the wound were measured using image analysis program. Result: Macroscopic observation showed fewer visible wound in the propolis extract treated group. Measurement by microscopic observation on day 3 also demonstrated more narrow wound width in propolis extract treated group (405.75  110.11 μ) compared to the control group (806.20 644.41μ). Conclusion: The result of this study suggests that propolis extract by oral administration promotes the healing of infected wound as shown within microscopic and microscopic observation.

BODY MASS INDEX (BMI) OF CHILDREN WITH TETRALOGY OF FALLOT (TOF) Ovin Nada Saputri; Viskasari P. Kalanjati; Mahrus A. Rahman
Majalah Biomorfologi Vol. 30 No. 1 (2020): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: Malnutrition is a common cause of morbidity and mortality amongst children with TOF. Objective: To analyze the BMI profile of children with TOF aged 0 – 18 years at Pediatric Department, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Materials and Methods: A cross-sectional study of the BMI from the medical record of TOF patients aged 0 – 18 years at the Pediatric Department, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, since January 2016 to December 2017 was conducted. The data included gender, age group, demographic distribution, weight, and height. BMI was calculated by WHO formula reference; body weight (kg) divided by body height squared (m2), which was converted into z-score histogram. BMI classification was guided by the Government’s Anthropometry Standards for Nutritional Status Assessment. Result: From 84 TOF patients, there were 43 males (51%) and 41 females (49%). The most dominant age group was 0 – 4 years old (n=47;56%). The majority of patients were from outside of Surabaya (n=64;76.2%). Based on their BMI, 36 patients (42.9%) had severe underweight, 10 patients (11.9%) were underweight, and 35 patients (41.7%) were normal, whilst the rests (3.6%) were overweight. Conclusion: The number of male patients was slightly higher than female patients. The majority of TOF patients were 0 – 4 years old and resided out town of Surabaya. The predominant BMI found was the underweight and severe underweight below normal BMI.

VARIABILITAS TEKANAN DARAH INTRADIALISIS PASIEN PENYAKIT GINJAL KRONIS DENGAN HEMODIALISIS BERKELANJUTAN Maulana Muhtadin Suryansyah; Mochammad Thaha; Budiono Budiono
Majalah Biomorfologi Vol. 29 No. 1 (2019): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: Various of studies report there was a link between changes in blood pressure during hemodialysis and the level of patient’s morbidity and mortality. Higher amount of mortality was found in groups of patients who have lower or higher blood pressure. Thus it is important to know the variability of blood pressure during hemodialysis. Objective: This study aims to determine blood pressure variability, namely systolic blood pressure and diastolic blood pressure during hemodialysis and determine the significance of changes in every hour of measurement. Material and method: The design of this study used a cross-sectional method with a total sample of 15 patients who have been diagnosed with Chronic Kidney Disease (CKD) and have been ungergone hemodialysis stably in the last 3 months. The data obtained were processed using paired T-Test and Wilcoxon test. Result: There was no significant difference in systolic blood pressure between hourly systolic blood pressure and a tendency to increase the mean systolic blood pressure during hemodialysis. In diastolic blood pressure, there was a difference between the mean diastole 3 and diastole 4, p = 0.007 (<0.05), while in other observation there were no significant differences. In the mean of diastolic blood pressure, there was a tendency to increase. Conclusion: During the hemodialysis process systolic blood pressure did not show a significant difference between the mean hours. In diastolic blood pressure, there was a significant difference between diastole 3 and diastole 4.

PROFIL PASIEN ENSEFALOKEL ANAK USIA 0 -18 TAHUN DI DEPARTEMEN BEDAH SARAF RSUD DR. SOETOMO SURABAYA Avida Marisa Ilmi; Viskasari Pintoko Kalanjati; Wihasto Suryaningtyas
Majalah Biomorfologi Vol. 29 No. 2 (2019): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: Data of encephalocele patient is rarely found in Indonesia, especially in East Java. Researcher conducted an observation aboutprofile of encephalocele patient age 0–18 years old at Department of Neurosurgery, Dr. Soetomo Hospital, Surabaya, Indonesia.Objective: To observe profile of encephalocele patient age 0–18 years at Department of Neurosurgery, Dr. Soetomo Hospital, Surabaya, Indonesia. Material and method: This is cross sectional observation research observing medical record of encephalocele patient age 0–18 years at Department of Neurosurgery, Dr. Soetomo Hospital, Surabaya, Indonesia from 2010 to 2012.This study also observeage groups, gender, address, and types of encephalocele. Results: 27 male and 23 female patients were included. From 5 types based on the defect location, 30 patients are diagnosed as nasofrontal encephalocele, nasoorbita is found at 17 patients, while nasofrontoorbita, maxilonasoorbita and nasoethmoorbita is found at 1 patient each. The most dominant age group is 0 – 3.5 years old (n=15). From 50 patients, 43 patients were from outside Surabaya.Conclusions: The number of male patients diagnosed with encephalocele were slightly higher compared to female patients. Nasofrontal type was the predominant type amongst other types. The majority of encephalocele patients were 0 – 3.5 years old. These patients mostly were from outside of Surabaya city.

EFFECT OF SEX DIFFERENCE ON THE HISTOLOGICAL STRUCTURE OF BRONCHUS AND NASAL CAVITY IN ANIMAL ASTHMA MODEL Reinaldi Rachmadhianto; Tri Hartini Yuliawati; Gatot Soegiarto
Majalah Biomorfologi Vol. 30 No. 1 (2020): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: The prevalence of asthma in prepuberty women is more common than in puberty men. Even after puberty, to a certain age, women dominate more. It is still unclear whether sex hormones affect the histological structure of male and female airways. Objective: This study objective was to examine the effect of sex difference on the histological structure of bronchial and nasal cavity of mice model (Mus musculus) with ovalbumin exposure. Materials and Methods: This study used 24 mice in four groups (male control, female control, male asthma model, and female asthma model). At the sensitization phase in days 0 and 14, the mice were injected intraperitoneally with 100 μl of a mixture of 50 μl ovalbumin (200 μl/ml) and 50 μl alum. At the exposure phase in days 21 to 23, the mice were exposed to 1% ovalbumin (aerosol, 30 minutes/per day). The mice were sacrificed 48 hours after the last exposure. The data taken included four variables, bronchial epithelial thickness, bronchial smooth muscle thickness, nasal cavity goblet cells number, and nasal cavity mucosal thickness. Then, Shapiro-Wilk normality test and parametric t-test were conducted. Results: In animal asthma models, mice with male and female exposure did not cause differences in epithelial thickness and smooth muscle thickness in bronchus compared to the control group. However, there were significant differences in the number of goblet cells and mucosal thickness in nasal cavity of male and female mice compared to the control group (respectively, p= 0.002; p= 0.006 and p= 0.003; p = 0.005). There were no significant differences between groups of male and female mice on all variables. Conclusion: In animal asthma models of mice, ovalbumin exposure did not cause differences in the values of all variables between male and female groups.

PENGGUNAAN ARCH BAR PADA FRAKTUR DENTOALVEOLAR Nicco Marantson
Majalah Biomorfologi Vol. 29 No. 1 (2019): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: Mandibular fracture is the most common case of craniofacial fracture. Nowadays, there are many methods available for treating mandibular fracture, and yet there has been no single method that can be applied to all fracture cases. Open reduction and rigid internal fixation is often used as a choice of treatment, but it needs surgical treatment and higher cost. Objective: To describe an alternative treatment for dentoalveolar fracture. Case: A 22-year-old man with simple mandibular dentoalveolar fracture due to traffic accident 12 days prior to patients’ visit to the dental hospital. Patient also suffered from zygomatic, infraorbital and frontal fractures. Mandibular dentoalveolar fracture was treated by debridement, surgical refracturing and fixation on mandibular teeth using arch bar only. Discussion: Abnormal function that is caused by dentoalveolar and bone destruction needs to be treated by anatomy reduction based on good occlusion. The advantages of non-surgical reposition are no scarring on extra oral features and lower risk of complication. Conclusion: Repositioning and fixation using arch bar without Intermaxillary Fixation (IMF) can be used as an alternative treatment in fixing mandibular fracture.

KARAKTERISTIK PASIEN KANKER SERVIKS DI RSUD DR. SOETOMO SURABAYA PERIODE JANUARI – DESEMBER 2017 Ahmad Fahrur Rozi; Dwi Susanti; Jimmy Yanuar Annas
Majalah Biomorfologi Vol. 29 No. 2 (2019): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: Cancer is one of mortality and morbidity throughout the world. The prevalence of cancer incidence in the world is still ranked highest after cardiovascular disease. In 2012 there were around 14 million new cancer cases and is estimated to increase around 70% over the next two decades. In Indonesia cervical cancer is cancer with highest numbers after breast cancer in women.Objective:This study aims to observe characteristics of age, marital status and clinical stage in patients with a diagnosis of cervical cancer. Material and method: The sample was all medical record of cervical cancer patients who had been treated at the Inpatient room/Obstetrics and Gynecology Installation in RSUD Dr. Soetomo Surabaya in period of January - December 2017. All patient’s medical record with cervical cancer within this period are incuded in research samples. The collected data is processed according toage, marital status and clinical stage cervical cancer. Then tabulation of data and descriptive statistical analysis of data that has been obtained. Result:The results of the study found 521 patient’s complete and unduplicated data including the age group diagnosed with cervical cancer, marital status and patient clinical stage. Conclusion: From the results of research regarding the characteristics of patients with cervical cancer diagnosis obtained information that the most age group is in the age range of 51-60 years (38.2%), almost 97.5% of married patients and mostly patients with cervical cancer are in the stage 3B (53.4%).

CHARACTERISTIC OF CHRONIC MYELOGENOUS LEUKEMIA PATIENTS AT THE POLYCLINIC OF ONCOLOGY, DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA IN 2017 M. Rifqi Wiyono; Siprianus Ugroseno Yudho Bintoro; Yetti Hernaningsi
Majalah Biomorfologi Vol. 30 No. 1 (2020): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm because of the reciprocal translocation of chromosome 22 to chromosome 9. In the United States, the incidence of CML is 1.9 cases per 100,000 people. Whereas in Indonesia, there is no specific national data on CML prevalence, especially regarding the clinical profile, even though the cancer cases reach 1.4 per 1,000 population. Objective: To evaluate the characteristics and clinical features of CML patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Materials and Methods: This was a cross-sectional descriptive study with data from the medical records of CML patients in 2017 at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. The sample in this study was CML patients with positive Breakpoint Clusters Region- Abelson (BCR-ABL), having a minimum age of 18 years and equipped with epidemiological data, complete blood count data, and peripheral blood smear data. Results: Thirty-three patients met the study criteria. The sample was predominantly male, with a ratio of 1.06 : 1 to female patients with a median age of 40 years. Spleno-megaly was found in 87.9% of the patients. The average results of leukocyte, platelet, and hemoglobin counts were 254.58 x 103/μL, 557 x 103/μL, and 9.55 g/dL. From the results of peripheral blood smear obtained normochromic normocytic anisopoikilo-cytosis erythrocyte (57.6%), all patients had a profile of increased leukocytes with blast presence in 97% of the patients, and 51.5% had a profile of an increase in platelets and the discovery of giant platelets in 33.3% of the patients. Conclusion: The sample was predominantly male with the highest incidence at a younger age range of 21-30 years. The clinical characteristics showed high leukocytosis with various stage of maturation and a tendency to develop grade 2 normocytic normochromic anemia and thrombo-cytosis was found in the patients.

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Viskasari P. Kalanjati

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+6285649348098

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Departemen Anatomi dan Histologi Fakultas Kedokteran, Universitas Airlangga, Surabaya, Indonesia Jl. Prof Dr Moestopo 47 Surabaya 60132 Indonesia

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Kota surabaya,

Jawa timur

INDONESIA