<![CDATA[The ethanol extract of (Psidium guajava L.) leaves, containing key phytocmhemicals such as tannins, flavonoids, and saponins, has demonstrated potential in enhancing wound repair. This research aimed to formulate a transdermal patch and investigate its in vivo wound-healing activity. Extraction was carried out through maceration of the simplicia using 96% ethanol as the solvent. Patches were formulated with HPMC and PVP, containing 2.5%, 5%, and 10% extract (F1, F2, F3). Physical evaluation (homogeneity, pH, thickness, adhesion) was performed. Rabbits (n=5) with a 2 cm dorsal incision were treated daily with patches (F1-F3), A negative control was represented by a (patch without extract) while the positive control used (povidone-iodine). Wound length was measured for 7 days. All evaluations met the physical requirements except pH at (F2: 6,6±0,1; F3: 6,8±0,1). F3 (10% extract) showed the highest wound healing activity, reducing wound length to 2 mm on day 7, significantly better than the control (7 mm) and lower concentrations (F1: 4 mm; F2: 3 mm). Guava leaf extract patches were effective at healing incised wounds, with concentration-dependent efficacy.]]>
Copyrights © 2025
