Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Volume 14. No. 1 January 2026

Inflammatory Marker and their Association with COVID-19 Severity in Pregnant Women

Yuyun Lisnawati (Deparment of Obstetric and Gynecology, Persahabatan Hospital Universitas Indonesia)
Akbar Purnadiputra (Faculty of Medicine Universitas Indonesia)
Lucky Savitry Widyakusuma (Deparment of Obstetric and Gynecology, Persahabatan Hospital Universitas Indonesia)
Sri Pudyastuti (Deparment of Obstetric and Gynecology, Persahabatan Hospital Universitas Indonesia)
Amanda Mustika Sari (Deparment of Obstetric and Gynecology, dr. Cipto Mangunkusumo General Hospital)



Article Info

Publish Date
14 Jan 2026

Abstract

Abstract : Objective: To analyze the correlation between blood markers; C-Reactive Protein (CRP), D-Dimer, Neutrophil-to-Lymphocyte Ratio (NLR) and the severity of COVID-19 in pregnant women during the 2020 pandemic at Persahabatan Hospital, Jakarta. Method :This cross-sectional study was conducted at Persahabatan Hospital, a National Respiratory Referral Center in Jakarta. A total of 525 pregnant women with confirmed COVID-19 who met the inclusion criteria were included in the study. Laboratory markers, including CRP, D-Dimer, and NLR, were analyzed and categorized as normal or elevated. Data were analyzed using the Chi-square test, and correlations were evaluated using Spearman’s rank correlation coefficient. Result :The results showed that elevated biomarkers were significantly correlated with increased disease severity. CRP (>10 mg/L), D-Dimer (>3333 mg/L), and NLR (?5.8) were all associated with moderate to severe disease. All biomarkers demonstrated a significant correlation with disease severity (p < 0.005). Conclusion: Elevated CRP, D-Dimer, and NLR levels are associated with increased disease severity in pregnant women with COVID-19, suggesting their potential role as practical indicators for disease severity assessment. Keywords : Covid 19, CRP, D-Dimer, NLR, Pregnant.

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Journal Info

Abbrev

journal

Publisher

Subject

Health Professions Medicine & Pharmacology Public Health

Description

The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published ...